Aims & Scope
Journal of Sinusitis (JS) publishes mechanistic research on the molecular pathophysiology, immunological pathways, microbial interactions, and biomarker discovery in sinonasal inflammatory diseases, with emphasis on understanding disease mechanisms rather than clinical management.
Molecular Pathogenesis
Immune Mechanisms
Microbial Dysbiosis
Biomarker Discovery
Disease Models
Scope Boundary: We do NOT consider clinical treatment protocols, surgical technique descriptions, patient management guidelines, or therapeutic outcome studies without mechanistic investigation.
Core Research Domains
Molecular Pathophysiology
- Inflammatory signaling pathways in chronic rhinosinusitis (CRS)
- Epithelial barrier dysfunction mechanisms in sinonasal mucosa
- Cytokine networks and immune cell activation in nasal polyposis
- Type 2 inflammation molecular signatures in eosinophilic CRS
- Cellular stress responses and tissue remodeling pathways
- Gene expression profiling in sinonasal inflammatory phenotypes
Typical Fit Example
"Transcriptomic analysis reveals distinct IL-33/ST2 pathway activation patterns in eosinophilic versus neutrophilic chronic rhinosinusitis endotypes"
Immunological Mechanisms
- Innate immune receptor signaling in sinonasal epithelium
- Adaptive immune responses and T cell polarization in CRS
- IgE-mediated mechanisms in allergic fungal rhinosinusitis
- Eosinophil activation pathways and degranulation mechanisms
- Neutrophil extracellular trap formation in acute sinusitis
- Immune dysregulation in aspirin-exacerbated respiratory disease
Typical Fit Example
"Mechanistic investigation of eosinophil peroxidase-mediated tissue damage in nasal polyp formation: role of oxidative stress pathways"
Microbial Pathogenesis
- Sinonasal microbiome composition and dysbiosis mechanisms
- Bacterial biofilm formation and persistence pathways
- Staphylococcus aureus virulence factors and superantigen effects
- Pseudomonas aeruginosa quorum sensing in chronic infection
- Fungal colonization mechanisms in allergic fungal sinusitis
- Host-pathogen interactions at mucosal surfaces
Typical Fit Example
"Molecular characterization of Staphylococcus aureus enterotoxin B-induced superantigen activation of T cells in nasal polyp tissue"
Biomarkers & Disease Models
- Discovery and validation of molecular biomarkers for CRS endotyping
- Proteomic signatures in sinonasal secretions and tissue
- Metabolomic profiling of inflammatory mediators
- In vitro models of sinonasal epithelial barrier function
- Animal models of chronic rhinosinusitis pathogenesis
- Organoid systems for studying sinonasal disease mechanisms
Typical Fit Example
"Development of air-liquid interface culture model to investigate epithelial-derived alarmin release in response to fungal allergen exposure"
Secondary Focus Areas
Cross-Disciplinary Mechanisms
- Unified airway disease: molecular links between CRS and asthma
- Neuroimmune interactions in sinonasal inflammation
- Metabolic factors influencing inflammatory pathways
- Environmental exposure effects on epithelial function
- Genetic susceptibility and epigenetic modifications
Methodological Innovations
- Novel imaging techniques for cellular pathway visualization
- Single-cell sequencing approaches in sinonasal tissue
- Spatial transcriptomics of inflammatory microenvironments
- Advanced proteomics and metabolomics platforms
- Machine learning for biomarker pattern recognition
Molecular Epidemiology
- Population-based genetic association studies
- Biomarker prevalence across demographic groups
- Environmental factor effects on molecular phenotypes
- Microbiome diversity patterns in populations
- Risk factor identification through omics approaches
Therapeutic Target Discovery
- Identification of novel molecular targets for intervention
- Mechanism of action studies for biologic agents
- Drug target validation in disease models
- Pathway-specific therapeutic approaches
- Resistance mechanisms to current therapies
Emerging Research Frontiers
Systems Biology Approaches
- Network analysis of inflammatory pathways
- Multi-omics integration for disease understanding
- Computational modeling of immune responses
- Systems-level biomarker discovery
Precision Medicine
- Molecular endotyping for personalized approaches
- Predictive biomarkers for treatment response
- Pharmacogenomics in sinonasal disease
- Patient stratification based on molecular profiles
Regenerative Mechanisms
- Epithelial repair and regeneration pathways
- Stem cell biology in sinonasal mucosa
- Tissue remodeling and fibrosis mechanisms
- Wound healing responses in chronic inflammation
Editorial Note: Submissions in emerging areas undergo additional editorial review to ensure mechanistic depth and alignment with pathophysiology focus. Studies must provide novel insights into disease mechanisms rather than descriptive observations.
Explicitly Out of Scope
We Do Not Consider
- Clinical Treatment Protocols Antibiotic regimens, corticosteroid dosing schedules, treatment algorithms, or therapeutic guidelines without mechanistic investigation
- Surgical Technique Descriptions Endoscopic approaches, procedural innovations, surgical outcomes, or operative methods unless investigating underlying pathophysiological mechanisms
- Patient Management Studies Clinical decision-making, care pathways, quality improvement initiatives, or healthcare delivery models
- Purely Clinical Outcomes Research Treatment efficacy trials, symptom scores, quality of life measures, or patient-reported outcomes without molecular/mechanistic endpoints
- Descriptive Case Reports Individual patient presentations, unusual clinical scenarios, or diagnostic challenges without mechanistic insights or biomarker discovery
Article Types & Editorial Priorities
Priority 1
Fast-Track Review
- Original Research Articles (mechanistic studies)
- Systematic Reviews & Meta-Analyses (pathophysiology focus)
- Methods & Resources (novel techniques for mechanism study)
- Biomarker Discovery & Validation Studies
Priority 2
Standard Review
- Short Communications (preliminary mechanistic findings)
- Data Notes (omics datasets, molecular profiles)
- Perspectives (mechanistic hypotheses, pathway discussions)
- Technical Notes (protocol optimizations)
Selective
Rarely Considered
- Case Reports (only if exceptional mechanistic insights)
- Opinion Pieces (must address pathophysiology controversies)
- Commentaries (on published mechanistic studies)
Editorial Standards & Requirements
ARRIVE Guidelines
Animal research reporting standards
STROBE Statement
Observational study reporting
PRISMA Guidelines
Systematic review standards
Data Transparency
Raw data deposition required
Ethics Approval
IRB/IACUC documentation mandatory
Preprint Policy
bioRxiv/medRxiv deposits encouraged
Data Policy: All omics data (genomics, transcriptomics, proteomics, metabolomics) must be deposited in appropriate public repositories (GEO, ProteomeXchange, MetaboLights) with accession numbers provided at submission. Code for computational analyses must be available via GitHub or similar platforms.
Decision Metrics & Timeline
21 days
First Decision
28%
Acceptance Rate
45 days
Publication Time
Open
Access Model
