Aplastic anaemia is a rare but serious bone-marrow failure syndrome in which the haematopoietic stem and progenitor cells are depleted, resulting in a hypocellular marrow and pancytopenia, the simultaneous reduction of red cells, white cells, and platelets in the peripheral blood. The consequent anaemia, neutropenia…
Aplastic anaemia is a rare but serious bone-marrow failure syndrome in which the haematopoietic stem and progenitor cells are depleted, resulting in a hypocellular marrow and pancytopenia, the simultaneous reduction of red cells, white cells, and platelets in the peripheral blood. The consequent anaemia, neutropenia, and thrombocytopenia produce fatigue and breathlessness, susceptibility to infection, and bleeding or bruising. Most cases are acquired and immune-mediated, in which cytotoxic T-lymphocytes attack haematopoietic precursors; other causes include exposure to drugs, chemicals, and radiation, viral infection, and inherited marrow-failure disorders. Diagnosis rests on the blood count, reticulocyte assessment, and bone-marrow examination, with exclusion of other causes of cytopenia. Management depends on severity and patient factors and includes supportive transfusion and infection prophylaxis, immunosuppressive therapy to abrogate the immune assault on the marrow, and allogeneic haematopoietic stem-cell transplantation for definitive restoration of blood-cell production. The condition sits within the broader study of haematopoiesis, immune dysregulation, and laboratory haematology, including the evaluation of cytopenias and platelet disorders. The peer-reviewed research surrounding this topic addresses laboratory testing and treatment approaches for immune thrombocytopenia and related cytopenias, together with experimental work on cellular and tissue biomarkers, reflecting the laboratory and immunological dimensions relevant to disorders of blood-cell production and the assessment of haematological function.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 39 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
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