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The antioxidant and membrane resistant peculiarities of a new derivative (2-cyan-3,4,4-trymethil-2-buten-4-olyd - CTBO) of cyan containing unsaturated lactones have been studied in membranes of hepatocytes with Sarcoma-45 1. The results of our previous research 123 showed significant changes of phospholipid (PL) exchange in hepatocytes of microsomal membranes at experimental animals vaccinated with Sarcoma-45 tumor strain. It is manifested in significant changes of quantitative and qualitative contents of membrane phospholipids separate fractions, increase of cytotoxic lysophospholipids (LPCs), phosphatidylinositol (PI) and phosphatidic acid (PA) levels, significant decrease of phosphatitylcholines (PC) and sphingomyeline (SP) contents, statistically significant changes of PL/PL ratio, peroxidation ratio intensity, dramatic increase of phospholipase A2 (PLA2)activity, quantitative and qualitative changes of adenyl nucleotides, as well as disorders of adenosine triphosphatase (ATPase) system activity 34567.
The cartilage surface was characterized using wettability test fresh and depleted AC samples. In this work, we demonstrated experimentally that the cartilage smart biomaterial at varies pH is sensitive to friction and introduces a novel concept in joint lubrication on charged surfaces.The surface charge density of the articular cartilage surface is related to the amphoteric character of phospholipids, PLs functional groups (-NH3+) and (-PO4-). The maximum surface energy of AC was found to occur at pH for isoelectric point ~4.5 (H3N+(CH2)n PO4- -R1R2) and with a wide range minimum of pH 6.5 to 9.5 of the phospholipidic membrane covering biological pH ~7.4 lubrication condition. The hydrophilic and hydrophobic character of cartilage was determined.