Research Topic · Peer-Reviewed

Langerhans Cells

Langerhans cells are specialised immune cells found mainly in the outer layers of the skin and in mucous membranes. They belong to the family of dendritic cells, which act as sentinels of the immune system. Derived originally from bone marrow precursors, Langerhans cells reside in the epidermis, where they continuou…

Curated from this journal's research 📚 4 peer-reviewed articles cited Cited 56× across the literature 🔖 ISSN 2578-8590 🗓 Reviewed July 2026

Overview

Langerhans cells are specialised immune cells found mainly in the outer layers of the skin and in mucous membranes. They belong to the family of dendritic cells, which act as sentinels of the immune system. Derived originally from bone marrow precursors, Langerhans cells reside in the epidermis, where they continuously sample their surroundings for foreign substances. When they encounter pathogens or other antigens, they capture and process this material and then migrate to nearby lymph nodes, where they present the antigens to T cells and initiate an immune response. In this way, Langerhans cells form a crucial link between the body's first physical barrier and its adaptive immune defences, helping to detect infections and coordinate protective reactions. They also play a role in maintaining immune tolerance and in skin-based immune surveillance. Because of their position at the interface between the body and the external environment, Langerhans cells are studied in relation to skin and mucosal immunity, inflammatory and infectious conditions, and the body's response to environmental exposures. Their function illustrates how the immune system integrates barrier tissues with systemic defence. This page gathers peer-reviewed, open-access research in the International Physiology Journal relevant to Langerhans cells and the immune physiology of the skin and mucous membranes.

Research published in this journal

4 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2014

Bioinformatics of Metabolomics in Diabetes Mellitus Type 2

Ahmad Sliem HamdyCorresponding author
Biochemistry and internal Medicine*, Basic oral and medical sciences, College of dentistry, Qassim University, Saudi Arabia
Bioinformatics And Diabetes Cited by 2 doi:10.14302/issn.2374-9431.jbd-13-212

How this research is being cited

The 4 articles above have been cited 56 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Langerhans Cells, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Physiology Journal (ISSN 2578-8590).

Journal editorial board
Carola Forster · Germany Ricardo J Fernandes · Portugal Alicja Kuban-Jankowska · Poland

This page summarises published research for orientation; it is not medical or professional advice.