Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. In contemporary terms it is defined by infection accompanied by acute organ dysfunction, with septic shock denoting a subset marked by profound circulatory and cellular-metabolic derangement, persistent hypotension requ…
Sepsis is life-threatening organ dysfunction caused by a dysregulated host response to infection. In contemporary terms it is defined by infection accompanied by acute organ dysfunction, with septic shock denoting a subset marked by profound circulatory and cellular-metabolic derangement, persistent hypotension requiring vasopressors, and elevated lactate. The underlying pathophysiology involves uncontrolled activation of inflammatory and coagulation pathways, endothelial injury, microvascular dysfunction, and impaired tissue oxygen utilization, which can progress to failure of the cardiovascular, respiratory, renal, and other systems and to manifestations such as lactic acidosis and acute respiratory distress. Early recognition through clinical and laboratory assessment, prompt source control, timely antimicrobial therapy, hemodynamic resuscitation, and organ support are decisive for survival, and risk-stratification tools and biomarkers assist prognostication and management. Sepsis remains a leading cause of in-hospital mortality across age groups, including neonates and surgical and critically ill patients, and recovery may require rehabilitation. The research reflected here includes rehabilitation of sepsis patients in intensive care, cardiac sequelae of severe sepsis, antimicrobial use in neonatal units, experimental systemic inflammatory response models, mortality risk scoring, and acidosis and respiratory complications. The journal publishes peer-reviewed studies on the pathophysiology, biomarkers, and clinical management of sepsis and critical illness.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 26 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Sepsis, linking to each citing work.