Research Topic · Peer-Reviewed

Lupus Erythematosus

Lupus erythematosus is a chronic autoimmune disease in which loss of immune tolerance to nuclear self-antigens drives the production of autoantibodies, immune-complex deposition, and inflammation across multiple organ systems. It encompasses a spectrum from cutaneous forms, such as discoid lupus, to systemic lupus e…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 74× across the literature 🗓 Reviewed June 2026

Overview

Lupus erythematosus is a chronic autoimmune disease in which loss of immune tolerance to nuclear self-antigens drives the production of autoantibodies, immune-complex deposition, and inflammation across multiple organ systems. It encompasses a spectrum from cutaneous forms, such as discoid lupus, to systemic lupus erythematosus (SLE), which can affect the skin, joints, kidneys, serous membranes, blood, and central nervous system. The pathogenesis integrates genetic susceptibility, including polymorphisms in immune-regulatory genes and transcription-factor pathways such as STAT4, with hormonal and environmental triggers that promote type I interferon signalling, B-cell hyperactivity, and defective clearance of apoptotic material. Characteristic autoantibodies, notably antinuclear and anti-double-stranded-DNA antibodies, support diagnosis alongside clinical criteria and complement and haematological markers, though the relapsing-remitting and multisystem nature of the disease makes recognition challenging. Lupus nephritis and haematological involvement are important determinants of prognosis, and management combines immunosuppressive and immunomodulatory therapy with monitoring of disease activity. Research relevant to this area addresses the genetic and computational analysis of susceptibility variants, overlapping neuroimmunological and autoimmune syndromes, autoantibody-mediated cytopenias, and the broader interplay of genes, inflammation, and environment in autoimmunity. The journal publishes peer-reviewed work on the immunopathogenesis, genetics, and clinical features of lupus and related autoimmune disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 74 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Lupus Erythematosus, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Inflammation Research.

Journal editorial board
Thomas Boldicke · Germany Graziella Curtale · Italy Frederic Velard · France

This page summarises published research for orientation; it is not medical or professional advice.