Research Topic · Peer-Reviewed

Mutation

A mutation is a change in the nucleotide sequence of an organism's genetic material, ranging from single-base substitutions to insertions, deletions and larger rearrangements. Mutations arise from replication errors, chemical damage or other mechanisms, and their consequences depend on where they occur and how they …

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 11× across the literature 🔖 ISSN 2692-1537 🗓 Reviewed July 2026

Overview

A mutation is a change in the nucleotide sequence of an organism's genetic material, ranging from single-base substitutions to insertions, deletions and larger rearrangements. Mutations arise from replication errors, chemical damage or other mechanisms, and their consequences depend on where they occur and how they alter gene products; they may be neutral, deleterious or, occasionally, advantageous. In viruses such as SARS-CoV-2, mutation in the genome, including the spike glycoprotein-coding region, drives molecular evolution and the emergence of variants, and computational approaches have been used to predict possible mutations and to compare viral lineages. In human genetics, specific mutations underlie defined disorders and clinical phenotypes: examples include factor V Leiden and plasminogen-activator-inhibitor variants associated with retinal vascular occlusion, a calcium-channel mutation linked to hypokalemic periodic paralysis, PRKAR1A mutation in Carney complex, LAMB3 mutation causing junctional epidermolysis bullosa, RPS19 mutation in Diamond-Blackfan anemia, and SMO mutation in a melanoma case. Mutations are also studied in developmental and evolutionary contexts, including models of speciation. Understanding mutation is therefore fundamental across virology, medical genetics and evolutionary biology, informing how pathogens adapt, how inherited and somatic diseases originate, and how genetic variation shapes biological diversity.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2021

A New Gene Mutation of PRKAR1A was found in a Carney Complex Case

Yang LiCorresponding author
Department of Endocrinology, Hunan Provincial People's Hospital (The First Affiliated Hospital of Hunan Normal University), Changsha, Hunan 410000, China.
Exact topic Clinical Case Reports and Images doi:10.14302/issn.2641-5518.jcci-21-3914
2020

The Novel Coronavirus 2019 (COVID-19): A Narrative Review

Rezapour BarataliCorresponding author
Department of Public Health, Faculty of Health, Assistant Professor, PhD in Health education and promotion, Urmia University of Medical Sciences, Urmia, Iran
Exact topic International Journal of Coronaviruses Cited by 2 doi:10.14302/issn.2692-1537.ijcv-20-3373
2020

SARS-CoV-2 affected cells Pathogeny and Therapy

M.R PonizovskiyCorresponding author
Kiev, Ukraine, “Kiev regional p/n hospital”, /Head of “Laboratory Biochemistry and Toxicology”
Exact topic International Journal of Coronaviruses doi:10.14302/issn.2692-1537.ijcv-20-3538

How this research is being cited

The 12 articles above have been cited 11 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Mutation, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Coronaviruses (ISSN 2692-1537).

Journal editorial board
Dr. Omeed Memar · USA Dr. SUDIPTI GUPTA · United States Dr. Jose Luis Turabian · Spain

This page summarises published research for orientation; it is not medical or professional advice.