Chemotherapy regimens are defined treatment protocols that specify the cytotoxic and related antineoplastic drugs used to treat cancer, together with their doses, routes of administration, sequence, and the timing and number of cycles. Rather than a single agent, regimens often combine drugs with complementary mecha…
Chemotherapy regimens are defined treatment protocols that specify the cytotoxic and related antineoplastic drugs used to treat cancer, together with their doses, routes of administration, sequence, and the timing and number of cycles. Rather than a single agent, regimens often combine drugs with complementary mechanisms of action to increase tumour-cell kill, target different phases of the cell cycle, and reduce the emergence of drug resistance, while spacing cycles to allow recovery of normal tissues. Regimens are selected according to tumour type, stage, molecular characteristics, and patient factors, and they may be given with curative or palliative intent. They are frequently integrated into multimodal treatment, used before surgery as neoadjuvant therapy to reduce tumour burden, after surgery as adjuvant therapy to eradicate residual disease, or in combination with radiotherapy, targeted agents, and immunotherapy. A defining challenge of regimen design is the balance between antitumour efficacy and toxicity, since cytotoxic drugs affect proliferating normal tissues, producing dose-limiting effects such as myelosuppression and disruption of haematopoiesis, alongside other organ-specific toxicities. Regimen development therefore considers drug interactions, dose intensity and scheduling, supportive care, and management across diverse settings and patient populations to optimise outcomes while limiting harm.
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