Research Topic · Peer-Reviewed

Acute Myeloid Leukemia

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy arising from the clonal proliferation of immature myeloid precursor cells, or myeloblasts, in the bone marrow and blood. Transformed blasts fail to differentiate and accumulate at the expense of normal haematopoiesis, producing anaemia, neutrop…

Curated from this journal's research 📚 6 peer-reviewed articles cited Cited 7× across the literature 🔖 ISSN 3070-1937 🗓 Reviewed June 2026

Overview

Acute myeloid leukaemia (AML) is an aggressive haematological malignancy arising from the clonal proliferation of immature myeloid precursor cells, or myeloblasts, in the bone marrow and blood. Transformed blasts fail to differentiate and accumulate at the expense of normal haematopoiesis, producing anaemia, neutropenia, and thrombocytopenia that manifest as fatigue, recurrent or severe infection, and bleeding. AML is biologically heterogeneous and is classified by morphology, immunophenotype, and increasingly by recurrent cytogenetic and molecular abnormalities, including chromosomal translocations and mutations that drive leukaemogenesis and carry prognostic significance. Aberrant expression of surface molecules implicated in proliferation and signalling, such as neuropilin-1, is among the markers studied to elucidate the disease's pathogenesis. Diagnosis relies on bone marrow examination, blast quantification, flow cytometry, and cytogenetic and molecular testing, which together guide risk stratification. Treatment typically combines intensive induction chemotherapy aimed at remission with consolidation, and, in selected patients, allogeneic haematopoietic stem cell transplantation; targeted agents directed at specific molecular lesions are increasingly used. Management is complicated by treatment-related cytopenias, infection during neutropenia, and immune complications following transplantation. Research spans the cellular and epigenetic basis of transformation, biomarker discovery, and supportive and cell-based therapeutic strategies that aim to improve remission rates and survival.

Research published in this journal

6 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2015

Epigenetics and Nutrition

Lundstrom KennethCorresponding author
PanTherapeuitcs, Rue des Remparts 4, CH1095 Lutry, Switzerland
Exact topic International Journal of Nutrition Cited by 2 doi:10.14302/issn.2379-7835.ijn-14-603
2018

Molecular Biomarkers: A Brief Review

Tarassishin LeonidCorresponding author
 Department of Biological Sciences.
Exact topic Proteomics and Genomics Research doi:10.14302/issn.2326-0793.jpgr-18-2418

How this research is being cited

The 6 articles above have been cited 7 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Acute Myeloid Leukemia, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Blood Transfusion (ISSN 3070-1937).

Journal editorial board
PROF OSARO ERHABOR · United Kingdom Nobu Akiyama · Japan Young-Kyun Lee · South Korea

This page summarises published research for orientation; it is not medical or professional advice.