Research Topic · Peer-Reviewed

Crohn s Disease

Crohn's disease is a chronic, relapsing inflammatory bowel disease characterized by transmural, granulomatous inflammation that can affect any segment of the gastrointestinal tract from mouth to anus, most often the terminal ileum and colon, typically in a discontinuous "skip lesion" pattern. Its pathogenesis involv…

Curated from this journal's research 📚 12 peer-reviewed articles cited Cited 39× across the literature 🗓 Reviewed July 2026

Overview

Crohn's disease is a chronic, relapsing inflammatory bowel disease characterized by transmural, granulomatous inflammation that can affect any segment of the gastrointestinal tract from mouth to anus, most often the terminal ileum and colon, typically in a discontinuous "skip lesion" pattern. Its pathogenesis involves a dysregulated mucosal immune response to the intestinal microbiota in genetically susceptible individuals, modulated by environmental factors and epithelial barrier dysfunction. Clinical features include abdominal pain, chronic diarrhea, weight loss, fatigue, and, in severe disease, complications such as strictures, fistulae, abscesses, ulceration, bleeding, and malnutrition. Diagnosis integrates endoscopy with histology and cross-sectional imaging, notably magnetic resonance enterography and computed tomography, to define disease extent, activity, and penetrating or stricturing complications. Management is guided by disease severity and phenotype and encompasses anti-inflammatory and immunomodulatory agents, biologic therapies, nutritional support including elemental and peptide-based formulas, and surgery for complications, while inflammatory signaling pathways are studied as therapeutic targets. The research reflected here addresses MR-enterography and CT diagnosis, identification of actionable imaging findings, granulomatous gastritis, candidate inflammatory therapy adjuvants, and nutritional and dietary interventions in gastrointestinal disease. The journal publishes peer-reviewed studies on the diagnosis, imaging, and management of inflammatory bowel disease.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

2019

Capsaicin: A Potential Therapy Adjuvant for Intestinal Bowel Disease

I Alvarez-Leite JacquelineCorresponding author
Departamento de Bioquímica e Imunologia, Instituto de Ciências Biológicas, Universidade Federal de Minas Gerias, Brazil.
Exact topic Digestive Disorders And Diagnosis Cited by 11 doi:10.14302/issn.2574-4526.jddd-19-3063

How this research is being cited

The 12 articles above have been cited 39 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Crohn s Disease, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in International Journal of Anesthesia.

Journal editorial board
John Bebawy · United States Pradipta Bhakta · Ireland Mainul Haque · United Kingdom

This page summarises published research for orientation; it is not medical or professional advice.