Animal models are non-human organisms used to study biological processes, model human disease, and evaluate the safety and efficacy of interventions under controlled conditions before clinical application. They range from rodents and larger mammals to fish and invertebrates, and may be naturally occurring, surgicall…
Animal models are non-human organisms used to study biological processes, model human disease, and evaluate the safety and efficacy of interventions under controlled conditions before clinical application. They range from rodents and larger mammals to fish and invertebrates, and may be naturally occurring, surgically or chemically induced, or genetically engineered to recapitulate specific pathologies. Animal models support mechanistic investigation, drug discovery, and toxicology, complemented increasingly by in silico and in vitro approaches and by ethical frameworks promoting refinement and replacement. The peer-reviewed research collected here employs and discusses animal models across many applications, including histo-morphological effects of plant extracts on gastrointestinal tissue, deep brain stimulation targets for epilepsy treatment, synthesis and evaluation of a tuberculosis imaging agent, development of cellular and molecular biomarkers using probiotic bacteria, and experimental zoology and drug-design progress spanning in silico, in vitro, and in vivo research. Further contributions address gene therapy for heart failure, animals in the COVID-19 era as source and sentinel, alternative-to-animal disease modeling platforms, and a novel analgesic drug candidate. Recurring themes include disease modeling, preclinical drug and biomarker evaluation, toxicological testing, and the ethical evolution toward complementary non-animal methods. Together these contributions frame animal models as essential tools that bridge basic biology and clinical translation, enabling controlled study of disease mechanisms and therapeutic candidates while increasingly integrated with emerging alternative approaches.
12 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The 12 articles above have been cited 31 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
A sample of recent works citing this journal's research on Animal Models, linking to each citing work.