Research Topic · Peer-Reviewed

Blood Protein Disorders

Blood protein disorders are conditions in which the plasma and cellular proteins that govern coagulation, oxygen transport, and immune defense are deficient, structurally abnormal, or functionally dysregulated. The category spans inherited deficiencies of clotting factors and their regulatory proteins, acquired coag…

Curated from this journal's research 📚 5 peer-reviewed articles cited Cited 19× across the literature 🔖 ISSN 2372-6601 🗓 Reviewed July 2026

Overview

Blood protein disorders are conditions in which the plasma and cellular proteins that govern coagulation, oxygen transport, and immune defense are deficient, structurally abnormal, or functionally dysregulated. The category spans inherited deficiencies of clotting factors and their regulatory proteins, acquired coagulopathies, hemoglobinopathies, and disorders of platelet-related and immune proteins. Mechanistically, these disorders arise when a gene mutation, autoantibody, or consumptive process alters the concentration or activity of a key protein within a tightly balanced network. Defects in coagulation factors and their inhibitors disrupt the procoagulant and anticoagulant equilibrium, producing either bleeding or thrombosis. Abnormalities of von Willebrand factor and the cleaving protease ADAMTS13, whether inherited or acquired in the setting of hematological malignancy, impair platelet adhesion and microvascular flow. Immune-mediated processes, as in immune thrombocytopenia, accelerate platelet destruction and require specific laboratory tests to distinguish them from production defects. Infections such as dengue can perturb plasma proteins and trigger coagulopathy and hemorrhage. Classification rests on the affected protein, whether the defect is quantitative or qualitative, and whether it is congenital or acquired. Accurate diagnosis depends on factor assays, inhibitor screens, and functional coagulation studies, and these distinctions guide replacement therapy, immunomodulation, and supportive transfusion management.

Research published in this journal

5 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 5 articles above have been cited 19 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

A sample of recent works citing this journal's research on Blood Protein Disorders, linking to each citing work.

Editorial oversight

Curated from peer-reviewed research published in Hematology and Oncology Research (ISSN 2372-6601).

Journal editorial board
Jayadev Manikkam Umakanthan · United States Shuaiying Cui · United States Benedetto Sacchetti · Italy

This page summarises published research for orientation; it is not medical or professional advice.