Overview
Adrenocorticotropic hormone (ACTH) is a hormone secreted by the anterior pituitary gland that stimulates the adrenal cortex to produce cortisol and other corticosteroids. By driving cortisol release, ACTH plays a central role in the body's response to stress and in the regulation of energy metabolism, blood glucose, blood pressure, and inflammation. Its secretion is governed by the hypothalamic-pituitary-adrenal axis through a feedback loop, in which corticotropin-releasing hormone from the hypothalamus prompts ACTH release and circulating cortisol in turn suppresses further production. Disturbances in this axis, whether from pituitary tumors, adrenal disease, or altered feedback, can produce conditions of hormone excess or deficiency with wide-ranging physiological effects. As a core topic in endocrinology, ACTH illustrates how the pituitary functions as a master regulator linking the nervous and endocrine systems. Research in this area examines pituitary structure and function, the hormonal signals that originate there, and the genetic and physiological factors that shape endocrine regulation, including studies of the anterior pituitary gland and inherited endocrine neoplasia syndromes. This page gathers peer-reviewed, open-access research relevant to pituitary and adrenal hormones and the regulation of the endocrine system.
Research published in this journal
3 peer-reviewed articles, ranked by relevance. Each links to its DOI.
The Genetic Multiplicity- Multiple Endocrine Neoplasia type I
A Rare Cause of Fever of Unknown Origin: Reverse Shapiro’s Syndrome
How this research is being cited
The 3 articles above have been cited 2 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.
-
2025 · Cureus
-
2025 · Cureus
A sample of recent works citing this journal's research on Adrenocorticotropic Hormone, linking to each citing work.