Liquid Chromatography-mass Spectrometry

Overview

Liquid chromatography-mass spectrometry (LC-MS) is an analytical technique that couples liquid chromatographic separation of components in a mixture with mass-spectrometric detection, enabling the identification and quantification of compounds in complex samples. Liquid chromatography separates molecules based on their physical and chemical interactions with a stationary and mobile phase, while the mass spectrometer measures the mass-to-charge ratio of ionized analytes, together providing high sensitivity, specificity, and structural information. LC-MS is widely applied across pharmaceutical analysis, food safety, environmental monitoring, clinical and bioanalytical testing, and metabolomics, and tandem configurations (LC-MS/MS) extend its selectivity for trace-level quantification. Research published under this topic includes reviews of LC-MS applications in food safety, structural characterization and isotopic abundance ratio analysis of pharmaceutical compounds, identification and quantification of adulterants in dietary supplements, and characterization of vitamins and drug substances using LC-MS and complementary GC-MS methods. Further work covers tandem mass spectrometry methods for determining drugs such as febuxostat and danshensu in plasma to support bioequivalence and pharmacokinetic studies, and the standardization of chromatographic-mass spectrometric test methods for contaminants of emerging concern, reflecting the technique's central role in modern qualitative and quantitative chemical analysis.

Research published in this journal

12 peer-reviewed articles, ranked by relevance. Each links to its DOI.

How this research is being cited

The 12 articles above have been cited 34 times in the scholarly literature. Citation data via OpenAlex and Crossref, updated Jun 2026.

• Metabolomics of Trichoderma spirale by Mass Spectrometry Data Dereplication
  2025 · Chemistry of Natural Compounds
• Pharmacokinetic Simulation and Area under the Curve Estimation of Drugs Subject to Enterohepatic Circulation
  Melchor Alpízar et al. · 2024 · Pharmaceutics
• Optimization and validation of a UPLC-MS/MS assay for simultaneous quantification of 2,8-dihydroxyadenine, adenine, allopurinol, oxypurinol and febuxostat in human plasma.
  U. Thorsteinsdóttir et al. · 2024 · Journal of chromatography. B, Analytical technologies in the biomedical and life sciences
• Determination of Phosphodiesterase Type-5 Inhibitors (PDE-5) in Dietary Supplements
  Oana Ramona Cătălina Gheorghiu et al. · 2023 · Molecules
• Determination of Phosphodiesterase Type-5 Inhibitors (PDE-5) in Dietary Supplements
  2023 · Molecules
• First Chemical Profile Analysis of Acacia Pods
  2023 · Plants
• LC/HRESI-MS/MS screening, phytochemical characterization, and in vitro antioxidant and cytotoxic potential of Jatropha integerrima Jacq. extracts
  2023 · Bioorganic Chemistry
• Synthesis, characterization and in vitro cytotoxicity of ruthenium(II) metronidazole complexes: Cell cycle arrest at G1/S transition and apoptosis induction in MCF-7 cells.
  Caio Cesar Candido et al. · 2022 · Journal of Inorganic Biochemistry

A sample of recent works citing this journal's research on Liquid Chromatography-mass Spectrometry, linking to each citing work.

This page summarises published research for orientation; it is not medical or professional advice.

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